MEMBRANE DEPOLARIZATION IS REQUIRED FOR PRESSURE-DEPENDENT PULMONARY ARTERIAL TONE BUT NOT ENHANCED VASOCONSTRICTION TO ENDOTHELIN-1 FOLLOWING CHRONIC HYPOXIA

Membrane depolarization is required for pressure-dependent pulmonary arterial tone but not enhanced vasoconstriction to endothelin-1 following chronic hypoxia

Enhanced vasoconstriction is increasingly identified as an important contributor to the development of Plant Cages pulmonary hypertension.Chronic hypoxia results in enhanced Rho kinase mediated Ca 2+ sensitization contributing to pressure-dependent pulmonary arterial tone as well as augmented vasoconstriction to endothelin-1 and depolarizing stimul

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